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    <ns6:brs_depositor xml:lang="en">Yumiko SAGA</ns6:brs_depositor>
    <dc:description xml:lang="ja">hesr3 locus LacZ がノックインされている。 neo 遺伝子は抜いていない。</dc:description>
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    <ns1:strainDevelopment xml:lang="ja">開発年：1999年 開発者：Hiroki Kokubo, Randy L Johnson 機関名：University of Texas M.D. Anderson Cancer Center</ns1:strainDevelopment>
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    <dcterms:identifier>RBRC01144</dcterms:identifier>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr01144'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
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    <ns6:brs_depositor xml:lang="ja">相賀　裕美子</ns6:brs_depositor>
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    <skos:altLabel xml:lang="ja">hairy and enhancer of split-related 3 Knock in (LacZ)</skos:altLabel>
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    <ns6:brs_depositorOrganization xml:lang="ja">国立遺伝学研究所</ns6:brs_depositorOrganization>
    <ns6:brs_depositorOrganization xml:lang="en">Natl. Inst. Genet.</ns6:brs_depositorOrganization>
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    <dc:description xml:lang="en">Developed by Drs. H. Kokubo and R.L. Johnson at University of Texas M.D. Anderson Cancer Center in 1999.  Combined loxP site and lacZ-Neo cassette was transferred into Heyl gene.</dc:description>
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    <ns1:strainDevelopment xml:lang="ja">開発年：1999年開発者：Hiroki Kokubo, Randy L Johnson機関名：University of Texas M.D. Anderson Cancer Center</ns1:strainDevelopment>
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    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって謝辞の表明を必要とする。</ns4:termsAndConditions>
    <ns1:strainDevelopment xml:lang="en">B6;129S7-Heyl&lt;tm1Kkb&gt;.  The Heyl gene is a member of the hairy and enhancer of split related family of bHLH transcription factors, play important roles in mediating the Notch signaling pathway.  It is suggested that the Heyl gene has a role of the differentiation of retina.  This strain is useful for elucidation of  the Notch-signaling pathway mechanism.</ns1:strainDevelopment>
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